Herpesvirus-Induced Antigens in Squamous-Cell Carcinoma in Situ of the Vulva
- 27 August 1981
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 305 (9), 483-488
- https://doi.org/10.1056/nejm198108273050903
Abstract
Antigens induced by herpes simplex virus Type 2 (HSV2) were found to be associated with squamous-cell carcinoma in situ of the vulva in nine of 10 patients. The HSV2-induced antigens are DNA-binding proteins that are normally present in the nuclei of infected cells, but in the cells of the carcinomas in situ they were found in the cytoplasm. Whole-virion structural antigens were not present, although there was serologic evidence of previous HSV2 infection in patients tested for the presence of antibodies. The observations reported here and the recent parallel rise in the prevalence of both HSV2 infections and vulvar carcinoma in situ, particularly in women under 40 years of age, suggest an association of HSV2 infection with this type of neoplasia, the nature of which remains to be determined. (N Engl J Med. 1981; 305:483–8.)This publication has 14 references indexed in Scilit:
- Cervical carcinoma: Detection of herpes simplex virus RNA in cells undergoing neoplastic changeInternational Journal of Cancer, 1980
- CARCINOMA INSITU OF THE VULVA1980
- Cervical Cancer Cell Lines Containing Herpesvirus MarkersIntervirology, 1979
- Immunohistochemical and electron microscopic detection of hepatitis B surface and core antigensExperimental and Molecular Pathology, 1978
- PRIMARY VULVAR NEOPLASIA - REVIEW OF INSITU AND INVASIVE CARCINOMA, 1935-19721977
- Expression of an early, nonstructural antigen of herpes simplex virus in cell transformed in vitro by herpes simplex virusJournal of Virology, 1977
- DNA-binding proteins induced by herpes simplex virus type 2 in HEp-2 cellsJournal of Virology, 1976
- DNA-Binding Proteins of Cells Infected by Herpes Simplex Virus Type 1 and Type 2Intervirology, 1976