BROMPTON MIXTURE VERSUS MORPHINE SOLUTION GIVEN ORALLY - EFFECTS ON PAIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 120 (4), 435-438
Abstract
The Brompton mixture is widely used as an effective method for controlling pain in cancer patients. In a double-blind crossover trial a standard Brompton mixture containing morphine, cocaine, ethyl alcohol, syrup BP and chloroform water was compared with morphine alone in a flavored aqueous solution. Both were administered orally. Pain was measured by means of the pain intensity index of the McGill Pain Questionnaire. Ratings of confusion, nausea and drowsiness were obtained from the patients and their nurses and relatives. There was no significant difference between the Brompton mixture and morphine administered orally for any of the variables. Both relieved pain effectively in about 85% of the patients.