The Antibody Response in Man Following Infection With Viruses of the pox Group: II. Antibody Response Following Vaccination
- 1 December 1958
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 56 (4), 466-478
- https://doi.org/10.1017/s0022172400037979
Abstract
Following primary vaccination no antibody was detected up to the tenth day. After this time neutralizing antibody and antihaemagglutinin were present in the majority of individuals, while, with the technique used, complement-fixing antibody was found in less than half those examined. Neutralizing antibody may be found in the blood more that 20 years after primary vaccination; by this time very few show antihaemagglutinin and then only in low titre. Complement-fixing antibody was not found more than 6 months after primary vaccination.In revaccinated individuals the antibody response tended to be higher than after primary vaccination and, when it occurred, often appeared within a week.This suggeststhat prompt revaccination of smallpox contacts may offer even greater protection than does primary vaccination.The neutralization test is a better measure of immunological response than are either of the other two tests, for these may give a negative result even though there may be a well-marked rise in neutralizing antibody. The ‘early’ type of reaction to revaccination was associated with an antibody response in only about half the subjects examined. In the remainder, the skin reaction, although identical in appearance, must be regarded as allergic in nature and not accompanied by increase in immunity.Keywords
This publication has 23 references indexed in Scilit:
- The Antibody Response in Man Following Infection with Viruses of the Pox Group III. Antibody Response in SmallpoxEpidemiology and Infection, 1958
- [The vaccine-hemagglutination inhibiting antibody titer of blood serum in different age groups].1957
- VACCINATION AGAINST SMALLPOX .2. JET INJECTION OF CHORIO-ALLANTOIC MEMBRANE VACCINE1956
- Some factors involved in the titration and neutralisation of vaccinia virusAntonie van Leeuwenhoek, 1953
- Vaccinia. Passive immunity in newborn infants: I. Placental transmission of antibodiesII. Response to vaccinationsThe Journal of Pediatrics, 1953
- THE SERUM ANTIBODY RESPONSE IN ALASTRIMThe Lancet, 1953
- STUDIES ON THE SEROLOGICAL DIAGNOSIS OF SMALLPOXThe Medical Journal of Australia, 1950
- A study of the pox viruses by complement fixation and inhibition of complement‐fixation methodsThe Journal of Pathology and Bacteriology, 1950
- THE VIRUSES OF VARIOLA, VACCINIA, COWPOX AND ECTROMELIA - NEUTRALIZATION TESTS ON THE CHORIO-ALLANTOIS WITH UNABSORBED AND ABSORBED IMMUNE SERA1950
- APPLICATION OF HIRST'S PHENOMENON TO THE TITRATION OF VACCINIA VIRUS AND VACCINIA IMMUNE SERUMThe Medical Journal of Australia, 1942