A Peroxisome Proliferator-Activated Receptor-γ Agonist Reduces Infarct Size in Transient but Not in Permanent Ischemia
- 1 February 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 36 (2), 353-359
- https://doi.org/10.1161/01.str.0000152271.21943.a2
Abstract
Background and Purpose— Activators of peroxisome proliferator-activated receptor-γ (PPARγ), a member of the PPAR family, increase levels of CuZn-superoxide dismutase (SOD) in cultured endothelium, suggesting a mechanism by which it may exert its protective effect within the brain. These properties raise the question of whether a PPARγ agonist may be neuroprotective in models of ischemia without reperfusion, in which oxidative injury is less prevalent. Methods— In 2 groups of rats, 90 minutes of middle cerebral artery (MCA) occlusion was followed by 1 day of reperfusion, with 1 group receiving pioglitazone (a PPARγ agonist) starting 72 hours before MCA occlusion (MCAO) and continuing through the day of occlusion, whereas the other group received vehicle only. In 2 comparable groups, the MCA was occluded permanently. One day after occlusion, the animals were tested neurologically and infarct volumes were calculated. In a separate group, rats were treated with pioglitazone or vehicle for 4 days. Tissue was o...Keywords
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