Sequential changes of KL-6 in sera of patients with interstitial pneumonia associated with polymyositis/dermatomyositis
Open Access
- 1 April 2000
- journal article
- other
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 59 (4), 257-262
- https://doi.org/10.1136/ard.59.4.257
Abstract
OBJECTIVE KL-6 is a mucin-like high molecular weight glycoprotein, which is strongly expressed on type II alveolar pneumocytes and bronchiolar epithelial cells. It has been demonstrated that the KL-6 antigen is a useful marker for estimating the activity of interstitial pneumonia. In this study, it is hypothesised that serum KL-6 is a useful marker to evaluate the activity of interstitial pneumonia associated with polymyositis/dermatomyositis (PM/DM). METHODS KL-6 was measured in sera in 16 patients diagnosed with PM/DM. Five had non-specific interstitial pneumonia (NSIP), three had diffuse alveolar damage (DAD), and eight had no pulmonary involvement, and 10 were normal non-smokers as a control group. The correlation was also evaluated between the KL-6 level and each clinical course in patients with pulmonary involvement associated with PM/DM. Immunohistochemical analysis using monoclonal anti-KL-6 antibody was also performed. RESULTS KL-6 concentrations in sera of patients with interstitial pneumonia associated with PM/DM were significantly high compared with those of PM/DM without interstitial pneumonia, and normal non-smokers. KL-6 concentrations in sera in patients with DAD significantly increased compared with those of other groups. KL-6 values in sera changed according to the progression or improvement of interstitial pneumonia. Immunohistochemical study using pulmonary tissues obtained from patients with DAD demonstrated that the hyaline membrane, proliferating type II pneumocytes, bronchial epithelial cells and some endothelial cells in pulmonary veins were stained by antihuman KL-6 antibody. CONCLUSION These data demonstrate that measurement of serum KL-6 was a useful marker to evaluate the activity of acute interstitial pneumonia associated with PM/DM.This publication has 13 references indexed in Scilit:
- KL-6: A Serum Marker for Interstitial PneumoniaChest, 1995
- KL-6, a Mucin-like Glycoprotein, in Bronchoalveolar Lavage Fluid from Patients with Interstitial Lung DiseaseAmerican Review of Respiratory Disease, 1993
- Circulating Antigen KL-6 and Lactate Dehydrogenase for Monitoring Irradiated Patients with Lung CancerChest, 1992
- Interstitial Lung Disease in Polymyositis and Dermatomyositis: Clinical Features and Prognosis as Correlated with Histologie FindingsAmerican Review of Respiratory Disease, 1990
- New Serum Indicator of Interstitial Pneumonitis ActivityChest, 1989
- Detection of Soluble Tumor-associated Antigens in Sera and Effusions Using Novel Monoclonal Antibodies, KL-3 and KL-6, against Lung AdenocarcinomaJapanese Journal of Clinical Oncology, 1988
- A novel method for screening monoclonal antibodies reacting with antigenic determinants on soluble antigens; a reversed indirect-enzyme linked immunosorbent assay (RI-ELISA).1987
- Acute interstitial pneumonia. A clinicopathologic, ultrastructural, and cell kinetic study.1986
- Polymyositis and DermatomyositisNew England Journal of Medicine, 1975
- INTERSTITIAL PNEUMONITIS IN DERMATOMYOSITISJAMA, 1956