Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes
Open Access
- 1 December 1971
- Vol. 12 (12), 984-987
- https://doi.org/10.1136/gut.12.12.984
Abstract
Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.Keywords
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