The Mechanism of Inhibition of Cellular Activity by Narcotics

Abstract

The literature dealing with the mechanism of narcotic action in vivo is reviewed. Inhibitors generally are classified as competitive or non-competitive. In the former category 2 types are found: (a) those which compete with the substrate for the enzyme; and (b) those which compete with the prosthetic group for the enzyme. In the latter category again 2 types are found: (a) inhibitors which combine with the prosthetic group; and (b) those which combine with the protein portion of the enzyme. Each type is analyzed equationally in terms of tissue enzyme chemistry. From discussion of the analyses a generalized scheme, based upon carbohydrate metabolism, is presented to indicate the possible site and mechanism, of action of the narcotics and other "indifferent" inhibitors.