Novel analogs of enkephalin: identification of functional groups required for biological activity
- 1 October 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (10), 1113-1122
- https://doi.org/10.1021/jm00184a010
Abstract
Novel tri and tetrapeptide analogs of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the 1st and 4th residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides had significant in vitro opioid-like activity [in guinea pig ileum] indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.This publication has 21 references indexed in Scilit:
- [D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide AnalgesicScience, 1976
- Tolerance and dependence evoked by an endogenous opiate peptide.Proceedings of the National Academy of Sciences, 1976
- Opiate receptor affinity of peptides related to Leu-enkephalinBiochemical and Biophysical Research Communications, 1976
- EFFECTS OF MORPHINE-LIKE AND NALORPHINE-LIKE DRUGS IN NONDEPENDENT, MORPHINE-DEPENDENT AND CYCLAZOCINE-DEPENDENT CHRONIC SPINAL DOG1976
- STRUCTURE-ACTIVITY-RELATIONSHIPS OF ENKEPHALINS IN STIMULATED GUINEA-PIG ILEUM1976
- A synthetic peptide with morphine-like pharmacologic actionLife Sciences, 1975
- Stereochemistry of .beta.-replacement reactions catalyzed by tyrosine phenol-lyaseJournal of the American Chemical Society, 1975
- Immunochemical Studies on the Poly-γ-D-glutamyl Capsule of Bacillus anthracis. II. The Synthesis of Eight Dipeptides and Four Tripeptides of Glutamic Acid*Biochemistry, 1966
- Synthesis of Angiotensins by the Solid-Phase Method*Biochemistry, 1965
- A New Concept on the Mode of Interaction of Narcotic Analgesics with ReceptorsJournal of Medicinal Chemistry, 1965