Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity
Top Cited Papers
- 1 September 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 40 (3), 355-360
- https://doi.org/10.1161/01.hyp.0000028589.66335.aa
Abstract
Humans have elevated serum uric acid as a result of a mutation in the urate oxidase (uricase) gene that occurred during the Miocene. We hypothesize that the mutation provided a survival advantage b...Keywords
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