Cutis Laxa
- 1 July 1975
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 111 (7), 861-873
- https://doi.org/10.1001/archderm.1975.01630190051004
Abstract
Specimens from one case each of acquired and congenital cutis laxa were examined by electron microscopy. Elastic fibers of the dermis and subcutaneous arteries and veins were found to have similar changes. Elastin was diminished and microfilaments were visible throughout the entire fiber. Electron-dense, amorphous or granular layers that alternate with relatively electron-light layers were deficient. This electron-dense substance was unevenly aggregated within or in the vicinity of elastic fibers. In the congenital case, the aggregation and deposition of the electron-dense substance was often pronounced. In the vein, deficient deposition of elastin and admixture of microfilaments and amorphous substance were also found. Such admixture was often encircled by fibroblasts or smooth muscle cells. In the artery, multiplication of basal lamina was seen. Collagen fibers and anchoring fibrils of the skin were normal.This publication has 5 references indexed in Scilit:
- Cross-Banded Filamentous Aggregation in the Human DermisJournal of Investigative Dermatology, 1974
- Studies on the Chemistry and Fine Structure of Elastic Fibers from Normal Adult SkinJournal of Investigative Dermatology, 1972
- Electron Microscopic Studies of Normal and Abnormal Elastic Fibers of the Skin*Journal of Investigative Dermatology, 1967
- Loose Skin (Cutis Laxa) Associated With Systemic AbnormalitiesArchives of Internal Medicine, 1965
- THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPYThe Journal of cell biology, 1963