Sequential karyotypes in non‐Hodgkin lymphoma: Their nature and significance
- 1 March 1990
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 1 (4), 270-280
- https://doi.org/10.1002/gcc.2870010403
Abstract
The examination of sequential karyotypes in hematologic disorders has demonstrated that karyotypic changes are often associated with concurrent changes in clinical behavior. Acquired abnormalities that recur among different patients may also suggest genomic areas important to tumor progression. We therefore examined sequential karyotypes in 21 patients with non‐Hodgkin lymphoma (NHL). Sixteen of the 21 karyotypes demonstrated changes, including the majority of 6 small lymphocytic, 11 follicular, and 4 intermediate and high‐grade diffuse lymphomas. The t(14;18)(q32;q21) occurred in ten initial karyotypes and was retained in all cases. The band most frequently affected by newly acquired abnormalities was 14q32 (n = 5); chromosomes 1 and 2 (n = 5, each), and the 17p arm (n = 4) were also commonly affected. The acquired deletion of all or part of 17p appeared to be associated with a poor prognosis. Histologic transformation and karyotypic change did not correlate. This study of sequential karyotypes in NHL 1) confirms the primary importance of the t(14;18), 2) suggests that the 14q32 band is involved frequently in both primary and secondary cytogenetic events, and 3) suggests other genomic regions of potential significance to progression.This publication has 31 references indexed in Scilit:
- Correlation of Secondary Cytogenetic Abnormalities With Histologic Appearance in Non-Hodgkin's Lymphomas Bearing t(14;18)(q32;q21)JNCI Journal of the National Cancer Institute, 1988
- Activation of thec-mycOncogene in a Precursor-B-Cell Blast Crisis of Follicular Lymphoma, Presenting as Composite LymphomaNew England Journal of Medicine, 1988
- Multiple Recurrent Genomic Defects in Follicular LymphomaNew England Journal of Medicine, 1987
- Multiple chromosome abnormalities in a drug resistant TdT positive B-cell leukemiaLeukemia Research, 1987
- Report of the committee on structural chromosome changes in neoplasiaCytogenetic and Genome Research, 1987
- Cytogenetic studies in non-Hodgkin lymphomas-Results from surgical biopsiesHereditas, 1986
- Evolution of tumours and the impact of molecular oncologyNature, 1985
- Fluorodeoxyuridine synchronization of bone marrow culturesCancer Genetics and Cytogenetics, 1983
- A simple G-banding techniqueThe Lancet, 1973
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971