The use of adult rat liver cultures in the detection of the genotoxicity of various polycyclic aromatic hydrocarbons
- 1 January 1981
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 3 (4), 477-487
- https://doi.org/10.1002/em.2860030408
Abstract
The hepatocyte primary culture (HPC)-DNA repair test and the adult rat liver epithelial cell (ARL)-hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutagenesis assay are 2 in vitro short-term tests that possess intrinsic capability for xenobiotic biotransformation. Both assays detected the genotoxocity of a variety of carcinogenic polycyclic aromatic hydrocarbons. These 2 tests, which embody intact cellular metabolism, are useful for the evaluation of this class of carcinogens and provide results that strengthen those obtained in tests dependent upon subcellular metabolism.This publication has 30 references indexed in Scilit:
- Critical importance of microsome concentration in mutagenesis assay with V79 Chinese hamster cellsMutation Research, 1979
- Short-term tests for carcinogens and mutagensMutation Research/Reviews in Genetic Toxicology, 1979
- Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay systemMutation Research, 1979
- Problems associated with the application of short‐term tests for mutagenicity in mass‐screening programsEnvironmental Mutagenesis, 1979
- Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cellsNature, 1978
- A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutationMutation Research, 1978
- Mutagen screening by a simplified bacterial fluctuation test: Use of microsomal preparations and whole liver cells for metabolic activationMutation Research, 1977
- Liver homogenate-mediated mutagenesis in Chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxinsMutation Research/Environmental Mutagenesis and Related Subjects, 1977
- A tier system approach to mutagen testingMutation Research, 1974
- Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for DetectionProceedings of the National Academy of Sciences, 1973