In 1935 the world's literature on the subject of the treatment of multiple sclerosis was reviewed by Brickner.1 He emphasized the factors which made scientific investigation in the field of treatment of multiple sclerosis difficult, the most important being the notorious unpredictability of the natural course of the disease, its remissions sometimes for long periods, the lack of agreement over suitable criteria for determining improvement or cure, the difficulty of obtaining long term follow-ups and the difficulty of an individual observer's accumulating large enough series of cases to be statistically valid. A tabular compilation of the results of treatment reported in the literature was made, including such measures as antiseptics (arsenic, antimony, mercury and suramin sodium), fever therapy, special vaccines and serums, quinine, sympathectomy and hypnotism. From this compilation Putnam2 prepared in 1939 a statistical analysis of the recovery incidence based on 1,407 cases reported. Of these, 665