Effect of Food on the Bioavailability of Prednisone

Abstract

Two commercial prednisone tablets were studied which were previously shown by Sullivan et al. to have the slowest and fastest in vitro rates of dissolution, and the slowest and fastest rise to peak plasma prednisolone concentrations in human beings. The effect of food on the absorption of these 2 tablets was studied in a crossover study, which also repeated the fasting conditions used in the previous study. Marked differences in mean prednisolone plasma concentrations during the 0-2 h absorption phase were observed between the 2 tablets again, but food did not affect either tablet with respect to mean plasma prednisolone concentrations.