Dyskeratosis Ichthyosiformis Congenita Migrans

Abstract

An interesting clinical picture characterized by slowly extending serpiginous and polycyclic lesions with raised edges, hyperkeratosis of the flexures, and hyperhidrosis of the palms, present from birth, in a woman aged 23, was first described by Comel,¹in 1949. The back, abdomen, and proximal parts of the extremities were mainly involved; the condition became more pronounced at puberty, but there were subsequently some remissions. Comel suggested the term "ichthyosis linearis circumflexa." In a review of the literature we were able to find only one further case report under this diagnosis. Frank's²patient (1956), a man, showed almost identical clinical features. The condition had appeared within the first three months of life and had persisted. We believe that the cases presented by Miescher,³in 1954,