Rotational behaviour elicited by intracerebral injections of apomorphine and pergolide in 6‐hydroxy‐dopamine‐lesioned rats. I: Comparison between systemic and intrastriatal injections
- 1 November 1985
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 125 (3), 519-527
- https://doi.org/10.1111/j.1748-1716.1985.tb07750.x
Abstract
Rotational behaviour in unilaterally 6-hydroxy-dopamine-denervated rats has been attributed to stimulation of dopamine receptors on striatal as well as limbic areas. In the present study the rotational behaviour elicited by local intrastriatal injections of apomorphine or pergolide was compared to the rotation elicited by systemic injections of the drugs. We found that intrastriatal injections induced rotational behaviour almost identical to the behaviour occurring after systemic treatment. Furthermore, studies of the spread of [3H]apomorphine in brain tissue showed that at the peak of rotation the radioactivity was confined within the limits of the striatum. Non-significant amounts of radioactivity was found in the nucleus accumbens. On the basis of these data we conclude that rotational behaviour elicited by systemic injections of apomorphine or pergolide originates from stimulation of striatal sites. The difference in rotational patterns elicited by these drugs is more likely to relate to differences in receptor stimulation within the striatum than differences in, for example, relative distribution between limbic and striatal areas.Keywords
This publication has 24 references indexed in Scilit:
- Rotational behaviour elicited by intracerebral injections of apomorphine and pergolide in 6-hydroxy-dopamine-lesioned rats. II: The striatum of the rat is heterogeneously organized for rotational behaviourActa Physiologica Scandinavica, 1985
- The dopamine D-1 antagonist SCH 23390 inhibits apomorphine but not pergolide induced rotationActa Physiologica Scandinavica, 1984
- Behavioural and Biochemical Studies With the Benzamide Sulpiride in RatsActa Psychiatrica Scandinavica, 1984
- Neurochemical effects of some ergot derivatives: A basis for their antiparkinson actionsJournal of Neural Transmission, 1981
- Characterization of normal and supersensitive dopamine receptors: Effects of ergot drugs and neuropeptidesJournal of Neural Transmission, 1981
- Rotation produced by administration of dopamine and related substances directly into the supersensitive caudate nucleusLife Sciences, 1978
- Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitroLife Sciences, 1978
- Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral SupersensitivityScience, 1977
- Feedback loop or output pathway in striato-nigral fibres?Nature, 1977
- Mesolimbic dopaminergic neurones in the rotational model of nigrostriatal functionNature, 1976