Derivatization of unprotected polynucleotides
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (18), 6513-6529
- https://doi.org/10.1093/nar/11.18.6513
Abstract
A simple and efficient method for attaching amines to the terminal 51-phosphate of unprotected oligonucleotides or nucleic acids in aqueous solution is described. The method is applicable to low molecular-weight amines,polypeptides, or proteins.Keywords
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