The effect of MHC compatibility between parasite–infected cell line and recipient in immunization against tropical theileriosis
- 1 January 1989
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 11 (1), 47-56
- https://doi.org/10.1111/j.1365-3024.1989.tb00647.x
Abstract
Lymphoblastoid cell lines, infected and transformed in vitro by a Moroccan stock of Theileria annulata, infected and immunized susceptible taurine catle, at cell doses of 108, 106, 104 and 102, regardless of whether the recipients were BoLA matched or mismatched to the donor cell line. The MHC relationship between the cell line and recipient did affect the severity of the clinical response to cell line immunization which may reflect differences in the specific priming of the immune response. At the highest cell doses the BoLA-mismatched recipients reacted more severely than the BoLA-matched. This study shows that, unlike the closely related parasite T. parva, there is no histocompatibility barrier to immunization using T. annulata-infected cell lines which could be achieved with as few as 102 allogeneic infected cells. The role of MHC compatibility between cell line and recipient in the priming of a protective immune response is discussed.Keywords
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