Activation of c‐type viruses during skin graft rejection in the mouse. Interrelationships between immunostimulation and immunosuppression
- 15 March 1975
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 15 (3), 493-502
- https://doi.org/10.1002/ijc.2910150315
Abstract
Both mouse‐tropic and zenotropic C‐type RNA viruses were activated in BALB/c mice during rejection reactions against skin grafts from mice differing at the major histocompatibility locus (A/J) or sharing this locus (DBA/2). Animals that maintained their skin grafts following immunosuppression with antilymphocyte serum (ALS) or cyclophosphamide had a much higher incidence of virus‐positivity than animals that did not receive ALS or cyclophosphamide, or that rejected their skin grafts despite immunosuppressive therapy. ALS itself activated type‐C viruses from a small proportion of BALB/c mice whereas cyclophosphamide alone did not. Type‐C viruses were detected in spleens and regional nodes draining skin‐graft sites between 1 and 2 weeks following transplantation; thereafter they reached maximum titers in spleens. Viruses were not detected at skin‐graft sites, in tails or in thymuses of grafted animals. Virus activation was associated with splenic histological changes consisting of germinal center formation, diffuse hyperplasia of reticulum cells, depletion of periarteriolar lymphocytes and hyperplasia of red pulp hematopoietic elements.Keywords
This publication has 23 references indexed in Scilit:
- Cellular immunity in the mouse: V. Further studies on leukemia virus activation in allogeneic reactions of mice: Stimulatory parametersCellular Immunology, 1975
- Cellular immunity in the mouse: IV. Altered thymic-dependent lymphocyte reactivity in the chronic graft vs host reaction and leukemia virus activationCellular Immunology, 1975
- S‐tropic murine type‐C viruses: Frequency of isolation from continuous cell lines, leukemia virus preparations and normal spleensInternational Journal of Cancer, 1974
- Mixed splenocyte cultures and graft versus host reactions selectively induce an “S-tropic” murine type C virusCell, 1974
- Human Polyomavirus Infection in Renal Allograft RecipientsBMJ, 1973
- RISK OF CANCER IN RENAL-TRANSPLANT RECIPIENTSThe Lancet, 1973
- Leukemia Virus Activation during Homograft RejectionScience, 1973
- TUMOR INDUCTION BY IMMUNOLOGICALLY ACTIVATED MURINE LEUKEMIA VIRUSThe Journal of Experimental Medicine, 1973
- Studies of the mechanism of induction of infectious murine leukemia virus from AKR mouse embryo cell lines by 5-iododeoxyuridine and 5-bromodeoxyuridineVirology, 1973
- NEOPLASTIC SEQUELAE OF ALLOGENEIC DISEASE III. HISTOLOGICAL EVENTS FOLLOWING TRANSPLANTATION OF ALLOGENEIC SPLEEN CELLSTransplantation, 1967