Response of Infant and Adult Mice to Lymphocytic Choriomeningitis Virus Infection

Abstract

Freshly isolated strains of lymphocytic choriomeningitis virus induced inapparent infection and immunity in infant mice. A mouse-adapted strain, however, caused obvious signs of infection and a high mortality rate among infant mice. Adult mice were fully susceptible to both freshly isolated and mouse-adapted virus. These findings are in keeping with the epizoology of the disease in naturally infected mouse colonies.