Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion
- 20 January 1973
- Vol. 1 (5846), 143-146
- https://doi.org/10.1136/bmj.1.5846.143
Abstract
The effect of orally administered prostaglandin E2 and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E2 compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E2 methyl ester and its isomer, 15 (R) 15-methyl-E2 methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.Keywords
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