The biosynthesis of phenols. Part X. Mutation and radioactive tracer studies relating to the biosynthesis of sulochrin

Abstract

Speculations of various authors concerning the biosynthesis of sulochrin are discussed. New evidence, derived from studies utilising mutants of Aspergillus terreus and from degradation of [¹⁴C]sulochrin prepared from cultures of this organism in media containing either [2-¹⁴C]acetic acid or [2-¹⁴C]malonic acid, favours a pathway involving combination of two units related in molecular structure to o-orsellinic acid.