Antispermatogenic Effect of Aspirin and its Prevention by Prostaglandin E2
- 24 April 2009
- journal article
- Published by Hindawi Limited in Andrologia
- Vol. 10 (2), 137-141
- https://doi.org/10.1111/j.1439-0272.1978.tb01328.x
Abstract
Aspirin treatment causes a decrease in Leydig cell function, change in Sertoli cell morphology and a subsequent decrease in Spermatid count. Administration of Prostaglandin E2 prevents the effect of Aspirin on the Sertoli cell morphology and Spermatid degeneration without significant improvement of the Leydig cell function. On the basis of these findings, a possible relationship between Prostaglandin and testicular spermatogenesis has been discussed.Keywords
This publication has 9 references indexed in Scilit:
- Effect of Sexual Maturation and Androgens on Prostaglandin Levels in Tissues of the Male Reproductive System in MiceEndocrinology, 1976
- MEIOSIS: A PROSTAGLANDIN RESPONSE THAT IS NOT INHIBITED BY ASPIRINBritish Journal of Pharmacology, 1975
- Prostaglandins of rat testisLipids, 1974
- Inhibitory effects of aspirin and indomethacin on the biosynthesis of PGE2 and PGF2αBiochemical and Biophysical Research Communications, 1974
- EFFECT OF ASPIRIN ON HUMAN SEMINAL PROSTAGLANDINSThe Lancet, 1971
- The lipid composition of maturing rat testis the effect of α-tocopherolBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1971
- SITES OF HORMONE PRODUCTION IN THE MAMMALIAN TESTIS, AND THEIR SIGNIFICANCE IN THE CONTROL OF MALE FERTILITYBritish Medical Bulletin, 1970
- QUANTITATIVE STUDY OF SPERMATOGENESIS IN THE HYPOPHYSECTOMIZED RATEndocrinology, 1955
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946