ONLY B LYMPHOCYTES INDUCE ACTIVE ENHANCEMENT OF RAT CARDIAC ALLOGRAFTS
- 1 March 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 29 (3), 259-261
- https://doi.org/10.1097/00007890-198003000-00020
Abstract
LEW rats were immunized 7 days before (LEW .times. BN)F1 heart transplantation with 107 BN donor cells, purified erythrocytes (RBC), peripheral blood (PBL), splenic, nylon-wool-adherent (B[bone marrow-derived cell]-enriched) or nylon-wool-nonadherent (T[thymus-derived cell]-enriched) lymphocytes. Allograft rejection was only significantly enhanced in animals pretreated with lymphocyte populations containing surface immunoglobulin (SIgG)-positive cells (PBL, splenic or B-enriched lymphocytes). Recipients immunized with RBC or T-enriched lymphocytes containing few, if any, SIgG-bearing B lymphocytes, showed no significant graft prolongation.This publication has 7 references indexed in Scilit:
- Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer.The Journal of Experimental Medicine, 1979
- The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.The Journal of Experimental Medicine, 1979
- Kidney alloantigens determined by two regions of the rat major histocompatibility complexImmunogenetics, 1978
- Tissue distribution and quantitation of la‐like antigens in the ratEuropean Journal of Immunology, 1978
- ATTEMPTS TO INDUCE IMMUNOLOGICAL ENHANCEMENT FOR KIDNEY ALLOGRAFTS IN RHESUS MONKEYSTransplantation, 1978
- RIDDLE OF KIDNEY GRAFT ENHANCEMENT1978
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977