Aminolysis of Esters or Lactones Promoted by NaHMDS - A General and Efficient Method for the Preparation of N-Aryl Amides

Abstract

An efficient method for the preparation of N-aryl amides from anilines, esters or lactones promoted by NaHMDS is described. Advantages of this new method include high yields and mild reaction conditions which tolerate functional groups such as ketones and halides.