Development of circadian rhythmicity and light responsiveness in the rat suprachiasmatic nucleus: a study using the 2-deoxy[1-14C]glucose method.
- 1 February 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (2), 1204-1208
- https://doi.org/10.1073/pnas.77.2.1204
Abstract
The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian rhythm in metabolic activity level as indicated by 2-deoxy[1-14C]glucose uptake. The development of this rhythm was investigated. No diurnal difference in uptake was evident in fetal rats 1-2 days before birth. A significant diurnal difference in SCN 2-deoxyglucose uptake was present on postnatal day 1, even in rats kept in constant darkness. By day 1, exposure to light at night increased the SCN metabolic levels. According to previous studies, on day 1 the SCN is poorly developed and contains few synapses. At this time the retinohypothalamic tract has not yet developed. Progressive functional maturation of the SCN was found through day 21, when the rhythm and light responsiveness resembled those of adult rats.This publication has 33 references indexed in Scilit:
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