In Vitro Anaphylactic Response to Polyhaptenic and Monohaptenic Simple Antigens

Abstract

Summary: The foregoing experiments confirm the observations of Landsteiner and van der Scheer, who showed that simple polyhaptenic antigens will produce anaphylactic responses in sensitized smooth-muscle strips. These reactions can be inhibited by the previous addition of univalent haptens and the inhibiting action is not removed by washing the tissue. One of the univalent haptens having a relatively large molecular size produced weak and delayed anaphylactic responses, although it gave no precipitation with homologous antiserum.