Activation of a K‐252b‐Sensitive Protein Kinase is Necessary for a Post‐Synaptic Phase of Long‐Term Potentiation in Area CA1 of Rat Hippocampus
- 1 June 1990
- journal article
- research article
- Published by Wiley in European Journal of Neuroscience
- Vol. 2 (6), 481-486
- https://doi.org/10.1111/j.1460-9568.1990.tb00439.x
Abstract
K-252b, a potent inhibitor of protein kinases blocked a late phase of long-term potentiation (LTP) in area CA1 of rat hippocampal slices, resulting in decremental LTP. It also prevented the slowly developing increase in sensitivity of CA1 neurons to iontophoretically administered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) which was seen in control slices that exhibit nondecremental LTP. However, K-252b applied 60–180 min after the induction of LTP had no effect on the potentiated synaptic and AMPA-induced responses. A K-252b-sensitive protein kinase may therefore be involved in a slowly developing postsynaptic component of LTP.Keywords
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