Synthesis of a 21-Residue Fragment of Human Proinsulin by the Polyamide Solid Phase Method
- 1 January 1981
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 362 (2), 833-840
- https://doi.org/10.1515/bchm2.1981.362.2.833
Abstract
The synthesis of human proinsulin fragment residues 40-60 by a solid phase method based on polydimethylacrylamide is described. Of the amino acids, 19 were introduced as N.alpha.-(9-fluorenylmethoxycarbonyl) derivatives; functional side chains were protected as t-butyl ethers and esters. The yield of highly purified 21-residue peptide was 56.5%.This publication has 12 references indexed in Scilit:
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