Antioxidant treatment in Spielmeyer-Sjögren's disease

Abstract

The data for 125 patients with Spielmeyer-Sjogren''s disease is presented. Antioxidant therapy was given to 49. A combination of vitamin E, vitamin C, methionine and BHT [butylated hydroxy toluene] was given to 27. As the disease began to progress, the treatment was changed to a combination of sodium selenite and vitamine E in 14 of the 27 patients. The same therapy was given to 22 children who had not received previous antioxidant supplementation. The number of positive and negative responses was nearly equal in the 2 treatment groups. The quality of the response was better in the selenite group and it was possible in some cases to stop for several years, at least, the deterioration which began during the original therapy.