Antibody Production in Inbred Strains of Mice
- 1 January 1953
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 70 (1), 61-67
- https://doi.org/10.4049/jimmunol.70.1.61
Abstract
Based on tests involving the use of 5 inbred strains of mice, evidence is presented which indicates that there is genetic variation in the ability of the mouse to produce demonstrable circulating antibody to either egg albumin or pneumococcus polysaccharide. From the results obtained by the use of the two chemically definable antigens, it is suggested that the mouse does not form antibody to antigens of different chemical constitution in an identical manner. Intra-abdominal injection of egg albumin incited the production of more antibody than intramuscular injection. The number of injections of polysaccharide—either 1 or 5—had no significant effect on antibody production. The age of the animals had a highly significant effect on antibody production, animals 2 months old producing much less than animals 4 to 5 months old. The sex of the animals had no effect.Keywords
This publication has 7 references indexed in Scilit:
- THE ADSORPTION OF PROTEINS ON ERYTHROCYTES TREATED WITH TANNIC ACID AND SUBSEQUENT HEMAGGLUTINATION BY ANTIPROTEIN SERAThe Journal of Experimental Medicine, 1951
- LOCALIZATION OF ANTIGEN IN TISSUE CELLSThe Journal of Experimental Medicine, 1950
- The Significance of Antigen in Animal TissuesThe Journal of Immunology, 1949
- NATURAL AND IMMUNE ANTIBODIES IN MICE OF LOW AND HIGH TUMOR STRAINS1949
- ANTITULARENSE SERUM: CORRELATION BETWEEN PROTECTIVE CAPACITY FOR WHITE RATS AND PRECIPITABLE ANTIBODY CONTENTJournal of Clinical Investigation, 1947
- STUDIES ON TULAREMIA .3. IMMUNIZATION OF MICE1947
- The preparation of precipitating sera for the identification of animal speciesThe Journal of Pathology and Bacteriology, 1943