Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication
- 12 March 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 235 (4794), 1376-1379
- https://doi.org/10.1126/science.2435003
Abstract
Azidothymidine and ribavirin both inhibit replication of human immunodeficiency virus in vitro and show promise of clinical utility in patients infected with this virus. In this study, the possible interactions of these drugs were examined in vitro, and a reproducible antagonism between azidothymidine and ribavirin was found to occur under a variety of experimental conditions. The mechanism responsible for this antagonism appeared to be inhibition of azidothymidine phosphorylation by ribavirin. Because similar effects may occur in vivo, clinical trials of these two drugs in combination must be performed only under carefully controlled conditions.Keywords
This publication has 21 references indexed in Scilit:
- Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.Proceedings of the National Academy of Sciences, 1986
- Promising Results Halt Trial of Anti-AIDS DrugScience, 1986
- Biochemistry and clinical applications of ribavirinAntimicrobial Agents and Chemotherapy, 1986
- RIBAVIRIN ENTERS CEREBROSPINAL FLUIDThe Lancet, 1986
- Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferonAntimicrobial Agents and Chemotherapy, 1986
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsAdvances in Enzyme Regulation, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- Metabolism of acyclovir in virus-infected and uninfected cellsAntimicrobial Agents and Chemotherapy, 1981
- Tritiated Thymidine Incorporation Does Not Measure DNA Synthesis in Ribavirin-Treated Human CellsScience, 1981