Effects of Cholestyramine on 1,2-Dimethylhydrazine-Induced Enteric Carcinoma in Germfree Rats

Abstract

Oral administration of 1,2-dimethylhydrazine (DMH) induced intestinal neoplasms in germfree rats. A supplement of 2% cholestyramine resin in the diet increased the frequency of DMH-induced intestinal tumors and accelerated malignant transformation. Bile acids in the cecal content were determined with and without cholestyramine to obtain a correlation between bile acid metabolism and enteric carcinogenesis.