Gastric Acid Secretion after Parenterally and Intragastrically Administered Histamine in Patients with Portacaval Shunt

Abstract

SEVERAL recent reports^{1 2 3 4 5} have suggested that peptic ulceration may be a complication of portal–systemic shunt surgery. It has been firmly established in dogs that gastric acid secretion is enhanced when portal blood is diverted around the liver by a variety of technics.^{6 7 8} This augmentation occurs in dogs not only in the fasting state^{9 , 10} and after test meals^{6 , 7 , 9 10 11} but also after the intrajejunal¹² or parenteral^{7 , 9 , 10 , 12} administration of histamine. It has also been reported that the experimental production of ulcer can be facilitated by alteration of the portal circulation.^{1 , 8 , 13} It is not clear whether these studies of gastric function in dogs are . . .