NATURE OF HISTAMINE RECEPTORS CONCERNED IN CAPILLARY PERMEABILITY
Open Access
- 1 February 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 59 (2), 349-351
- https://doi.org/10.1111/j.1476-5381.1977.tb07499.x
Abstract
1Histamine and 2-methyl-histamine (H1-receptor agonist) caused dose-dependent increases in capillary permeability in albino mice, but 4-methyl-histamine (H2-receptor agonist) caused no significant increase. 2Mepyramine (H1-receptor antagonist) blocked the histamine-induced increase in capillary permeability whereas burimamide (H2-receptor antagonist) produced no significant blockade of the histamine-response. 3Combined mepyramine and burimamide pretreatment did not give any significantly greater protection than mepyramine alone. 4The results indicate involvement of the H1-receptors in histamine-induced increase in capillary permeability.Keywords
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