Importance of Sulfadiazine Resistance in Meningococcal Disease in Civilians

Abstract

THE first known concentration of cases of meningitis due to sulfadiazine-resistant strains of meningococci occurred during the spring of 1963 at the United States Naval Training Center in San Diego, California.¹ Most of the resistant organisms detected during the Naval Training Center outbreak belonged to serologic Group B, and some were resistant to more than 25 mg. of sulfadiazine per 100 ml.¹ Because the patterns of sulfadiazine resistance of meningococci isolated from military recruits might be expected to reflect, perhaps in accentuated form, those in civilians in the region, it seemed desirable to assess the prevalence of resistant strains among . . .