HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.
- 1 July 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (7), 4247-4250
- https://doi.org/10.1073/pnas.77.7.4247
Abstract
The specificity of cytotoxic T[thymus-derived] cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14 day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. The cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition test, strongly indicate that T cell cytotoxicity to EBV is restricted by HLA antigens.This publication has 17 references indexed in Scilit:
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