Further observations on immunization of sheep against Schistosoma mansoni and S. bovis using irradiation -attenuated schistosomula of homologous and heterologous species
- 6 April 1979
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 78 (2), 185-193
- https://doi.org/10.1017/s0031182000049234
Abstract
SUMMARY: This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiated schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated S. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection.Keywords
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