SIMULTANEOUS DETERMINATION OF THE PULMONARY AND SYSTEMIC CIRCULATION TIMES IN MAN AND OF A FIGURE RELATED TO THE CARDIAC OUTPUT

Abstract

An easily quantitated substance is injected into the venous side of the vascular bed, and its concentration determined in successive timed samples of the blood of the arterial side. By plotting these successive concentrations against time, it is possible to arrive at a curve whose landmarks give the greater and lesser circulation times, and whose average height gives a figure derived from the dilution of the injected substance by the blood[long dash]a figure which is probably very closely related to the cardiac output.