Intestinal Permeability to [51Cr]EDTA in Children with Cystic Fibrosis
- 1 May 1986
- journal article
- research article
- Published by Wiley in Journal of Pediatric Gastroenterology and Nutrition
- Vol. 5 (3), 384-387
- https://doi.org/10.1097/00005176-198605000-00008
Abstract
Intestimal permeability was investigated in 14 children with cystic fibrosis making use of [51 Cr] EDTA as probe molecule. Ten normal young adults and 11 children served as controls. After oral administration of [51Cr]-EDTA, 24 h urine was collected. Urinary radioactivity was calculated and results expressed as percentage of oral dose excreted in 24 h urine. Mean and SEM were as follows: 2.51 .+-. 0.21, 2.35 .+-. 0.24, and 13.19 .+-. 1.72 for control children, normal adults, and cystic fibrosis patients, respectively. The permeability differences between cystic fibrosis patients and either control children or control adults are significant (p < 0.001).Keywords
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