Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels
Open Access
- 1 October 1984
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 83 (2), 519-525
- https://doi.org/10.1111/j.1476-5381.1984.tb16516.x
Abstract
1 The contractile effect of neuropeptide Y (NPY) was tested on isolated segments of basilar artery, central ear artery, gastro-epiploic artery and vein, and femoral artery and vein from the rabbit. At 30 nM NPY did not evoke vasoconstriction; at 300 nM NPY evoked a weak and variable response. 2 NPY greatly potentiated the response of the gastro-epiploic and femoral arteries to noradrenaline without affecting the maximum response. As tested on the gastro-epiploic artery NPY was effective at concentrations of 1 nM and higher. As tested on the femoral artery the potentiating effect of 30 nM NPY on noradrenaline-evoked contractions was apparent immediately and 30 min after the application of NPY, but not after one hour. 3 NPY (30 nM) potentiated the contractile response to noradrenaline and histamine but not to 5-hydroxytryptamine or high K+. The response to histamine was augmented in both arteries and veins, whereas the response to noadrenaline was enhanced in arteries but not in veins. NPY failed to potentiate the prostaglandin F2α-evoked contraction except in the gastro-epiploic vein.This publication has 10 references indexed in Scilit:
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