High Allergen Exposure as a Risk Factor for Asthma and Allergic Disease
- 1 January 2005
- journal article
- Published by Springer Nature in Clinical Reviews in Allergy & Immunology
- Vol. 28 (1), 025-042
- https://doi.org/10.1385/criai:28:1:025
Abstract
The association between pet ownership in childhood and subsequent asthma and sensitization is very controversial. Intriguing, but contradictory, reports have caused considerable uncertainty in parents who wish to avoid asthma and allergic disease in their children. This article argues that high allergen exposure is a risk factor for asthma and allergic disease. It describes dispersal of pet allergens in society and critically assesses epidemiological studies regarding how early exposure to pet allergens affects subsequent immunoglobulin E-sensitization and allergic diseases. Additionally, this article evaluates the effects of allergen exposure in already sensitized subjects with asthma. Cat and dog allergens are ubiquitous in society and may induce sensitization and allergic symptoms in predisposed individuals, regardless of pet ownership. This, in combination with selection mechanisms for pet ownership in families with a history of allergic diseases, makes it difficult to study associations between early exposure to pets and subsequent allergic disease. Nevertheless, exposure to pet allergens worsens asthma in already sensitized children. Thus, it is clear that clinicians should advise sensitized asthmatics that avoidance of exposure to indoor allergens is an important element in the treatment of allergic disease.Keywords
This publication has 94 references indexed in Scilit:
- The pattern of atopic sensitization is associated with the development of asthma in childhoodJournal of Allergy and Clinical Immunology, 2001
- What should we tell allergic families about pets?Journal of Allergy and Clinical Immunology, 2001
- Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopyJournal of Allergy and Clinical Immunology, 2001
- Systematic review: Exposure to pets and risk of asthma and asthma-like symptomsJournal of Allergy and Clinical Immunology, 2001
- Atopy among schoolchildren in northern and southern Sweden in relation to pet ownership and early life eventsPediatric Allergy and Immunology, 2001
- Assessment of vacuum cleaners and vacuum cleaner bags recommended for allergic subjectsJournal of Allergy and Clinical Immunology, 1999
- Cat shedding of Fel d I is not reduced by washings, Allerpet-C spray, or acepromazineJournal of Allergy and Clinical Immunology, 1995
- House dust mite and cat allergen in different indoor environmentsClinical and Experimental Allergy, 1994
- Correlations between levels of mite and cat allergens in settled and airborne dustJournal of Allergy and Clinical Immunology, 1989
- The effect of cat removal on allergen content in household-dust samplesJournal of Allergy and Clinical Immunology, 1989