THE BINDING OF PENICILLIN IN RELATION TO ITS CYTOTOXIC ACTION
Open Access
- 1 July 1954
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 100 (1), 117-124
- https://doi.org/10.1084/jem.100.1.117
Abstract
1. (a) Mammalian cells in tissue culture (mouse fibroblasts and malignant human uterine epithelium) did not concentrate penicillin from the culture medium. Even at low concentrations, the cellular accumulation was usually less than that in the surrounding fluid, and most of it was removed by washing. The radioactive material in such eluates was actively bactericidal, and was presumably in large part unchanged penicillin.Keywords
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