Optimization of a Reverse Phase Ion-Pair Chromatographic Separation for Drugs of Forensic Interest Part II - Factors Effecting Selectivity

Abstract

Variables effecting selectivity for a reverse phase ion-pair chromatographic separation are examined for various drugs of forensic interest. Factors studied include type of stationary phase, ratio of water to methanol, size and concentration of counter-ion anc basicity of drug chromatographed. Most of the selectivity effects can be explained by Horvath's solvophobic theory.