THE REVERSIBLE INHIBITION OF MUSCLE GLYCOLYSIS

Abstract

In small conc. phenyl-mercuric hydroxide, p-chloromercuribenzoic acid and HgCl2 inhibit glycolysis in extracts of frogs'' muscle. This inhibition may be abolished by the use of cysteine or glutathione. The degree of inhibition depends on the conc. of the Hg compound. A block in the glycolytic mechanism occurs probably at the hexose state. An inhibition produced by I is also reversible, the reactivants used being cysteine, glutathione and ascorbic acid. This is tentatively interpreted in terms of an oxidative-reductive control of catalysis of the glycolytic process in frogs'' muscle.