In Vivo-Induced Genes in Pseudomonas aeruginosa
Open Access
- 1 April 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (4), 6962-6969
- https://doi.org/10.1128/iai.68.4.2359-2362.2000
Abstract
In vivo expression technology was used for testing Pseudomonas aeruginosa in the rat lung model of chronic infection and in a mouse model of systemic infection. Three of the eight ivi proteins found showed sequence identity to known virulence factors involved in iron acquisition via an open reading frame (called pvdI ) implicated in pyoverdine biosynthesis, membrane biogenesis (FtsY), and adhesion (Hag2).Keywords
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