Congenital malformations such as syndactylism, talipes, and paralysis agitans of nutritional origin were produced in swine. The basal ration used in these experiments was found to be deficient in a factor or factors necessary to support normal reproduction and lactation in the sow. Reproduction of the sow when fed the basal ration was defective as shown by the embryological abnormalities, and lactation was extremely poor, as is indicated by the number, appearance, and weight of the pigs when weaned. Supplementing the milk diet of the suckling pigs from sows fed the basal ration with pyridoxine, choline chloride, solubilized liver extract, 1–20 liver concentrate powder, calcium pantothenate, riboflavin, wheat germ oil, alpha tocopherol, shark liver oil, nicotinic acid, thiamin, and ascorbic acid either singly or in various combinations (at the levels used) failed to improve the appearance of the pigs or accelerate growth. Good quality alfalfa meal when added to the basal ration carries a factor or factors which wholly or in part corrects the deficiencies of the basal ration. Alfalfa meal varies greatly, however, in the potency of this factor or factors.