Total Synthesis of (−)-Reserpine Using the Chiron Approach
- 1 February 1997
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 62 (3), 465-473
- https://doi.org/10.1021/jo961713w
Abstract
A highly stereocontrolled synthesis of ring D/E precursor to reserpine has been developed starting from (−)-quinic acid as a chiral template. The total synthesis of (−)-reserpine is described through the cyclization of an immonium lactam intermediate.Keywords
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