SUPPRESSION OF PROLACTIN AND THYROTROPIN SECRETION IN THE RAT BY ANTISERUM TO THYROTROPIN-RELEASING HORMONE

Abstract

Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to male and female rats caused a 50% and a 70% suppression in serum levels of prolactin and thyrotropin, respectively, as compared with controls injected with normal rabbit serum. The degree of suppression was similar in diestrous and proestrous female rats and in male rats. In addition to its original designation, TRH probably also has a physiological role in regulating the release of pituitary prolactin.