HLA‐Bw54 (Bw22‐J, J‐1) Antigen in Juvenile Onset Diabetes Mellitus in Japan
- 1 May 1978
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 11 (5), 418-422
- https://doi.org/10.1111/j.1399-0039.1978.tb01277.x
Abstract
HLA—B8 and/or Bw15, associated with juvenile onset insulin‐dependent diabetes mellitus (JDM) in Caucasians, have a very low frequency in the Japanese population. Thus, we were interested in investigating the association between JDM and HLA antigen in a Japanese population. Eighty‐nine patients with JDM and 128 unrelated random controls were HLA‐typed by the micro‐lymphocytotoxicity test. The data revealed a significant, positive association between this type of diabetes mellitus and HLA‐Bw54 (Bw22‐J, J‐1) antigen (Japanese‐specific split antigen of HLA—Bw22).Keywords
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